Across TCGA cell cohorts, SIRT7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,771 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SIRT7-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Actomyosin contractile ring organization. Each is linked with SIRT7 in more than 17 cancer types. Because this analysis shows association rather than direction, both SIRT7-to-partner and partner-to-SIRT7 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT7→partner) and Y-score (partner→SIRT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.167	+1.143	<.001	<.001	3	18
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.131	+0.907	<.001	<.001	3	17
BONE	Actomyosin contractile ring organization →	+0.163	+0.834	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Respiratory burst after phagocytosis →	+0.245	+0.841	.008	.007	2	14
BONE	Pre-mRNA catabolic process →	+0.187	+0.861	<.001	<.001	3	12
BONE	Assembly of actomyosin apparatus involved in cytokinesis →	+0.261	+1.362	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,771 associations by consensus.

Exploration

SIRT7 survival (RNA) · tumor vs normal (RNA) · all SIRT7 data types