Across TCGA cell cohorts, SIRT7 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIRT7-associated genes across cancer lineages are LMNTD1, PYDC1, and MAGEB10. Each is linked with SIRT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT7-to-partner and partner-to-SIRT7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT7→partner) and Y-score (partner→SIRT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LMNTD1 →	+0.116	+3.554	.006	.007	3	1
LARGE_INTESTINE	PYDC1 →	+0.177	+3.347	.006	.005	3	1
LARGE_INTESTINE	MAGEB10 →	+0.072	+3.345	<.001	.007	3	1
LARGE_INTESTINE	SHISA8 →	+0.392	+3.626	<.001	.006	3	1
LARGE_INTESTINE	WSCD2 →	+0.104	+3.660	.009	.005	3	1
BLOOD_Leukemia	INSM2 →	+0.309	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

SIRT7 survival (RNA) · tumor vs normal (RNA) · all SIRT7 data types