SIRT1

Across TCGA patient cohorts, SIRT1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,770 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SIRT1-associated genes across cancer lineages are SMC3, GKAP1, and MAPK8. Each is linked with SIRT1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIRT1-to-partner and partner-to-SIRT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIRT1 versus SMC3 in BRCA, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT1→partner) and Y-score (partner→SIRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC3 →	+0.477	+0.250	.001	.003	3	6
LSCC	GKAP1 →	+0.655	+0.362	.001	<.001	3	6
BRCA	MAPK8 →	+0.557	+0.267	<.001	<.001	3	5
COAD	PPP3CB →	+0.507	+0.436	.005	.006	3	5
LSCC	DNA2 →	+0.854	+0.369	<.001	<.001	3	5
BRCA	MRPS16 →	+0.487	+0.324	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,770 associations by consensus.

SIRT1 vs SMC3 — BRCA

Explore this scatter interactively →