SIRT1

Across TCGA cell cohorts, SIRT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,975 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIRT1-associated GO terms across cancer lineages are Triglyceride mobilization, Regulation of sister chromatid cohesion, and Positive regulation of double-strand break repair. Each is linked with SIRT1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SIRT1-to-partner and partner-to-SIRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Triglyceride mobilization grouped by SIRT1-low versus SIRT1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT1→partner) and Y-score (partner→SIRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Triglyceride mobilization →	+0.208	+0.544	.003	<.001	3	16
LUNG_NSCLC_LUSC	Regulation of sister chromatid cohesion →	+0.156	+0.927	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.094	+1.020	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Subtelomeric heterochromatin formation →	+0.100	+0.716	.003	.001	3	16
BONE	Peptidyl-lysine acetylation →	+0.142	+0.859	<.001	<.001	3	16
BLOOD_Lymphoma	DNA synthesis involved in DNA repair →	+0.104	+1.319	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,975 associations by consensus.

Triglyceride mobilization by SIRT1 expression — LUNG_SCLC

Explore this box plot interactively →