SIRT1

Across TCGA cell cohorts, SIRT1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIRT1-associated genes across cancer lineages are DEFA6, LRRC10, and PRAMEF19. Each is linked with SIRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT1-to-partner and partner-to-SIRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA6 grouped by SIRT1-low versus SIRT1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT1→partner) and Y-score (partner→SIRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFA6 →	+0.157	+5.228	<.001	.005	3	2
BLOOD_Leukemia	LRRC10 →	+0.220	+4.129	<.001	.009	3	2
LUNG_NSCLC_LUAD	PRAMEF19 →	+0.016	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.022	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

DEFA6 by SIRT1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →