SIRPG

Across TCGA patient cohorts, SIRPG mutation is significantly associated with the RNA expression of many other genes, with 1,885 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRPG-associated genes across cancer lineages are BEX4, MIR190B, and CLEC4F. Each is linked with SIRPG in more than 2 cancer types. Because this analysis shows association rather than direction, both SIRPG-to-partner and partner-to-SIRPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BEX4 grouped by SIRPG-low versus SIRPG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPG→partner) and Y-score (partner→SIRPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BEX4 →	-1.222	-3.676	<.001	.001	3	3
LUSC	MIR190B →	+0.481	+3.978	<.001	.001	3	3
UCEC	CLEC4F →	-0.634	-2.393	.007	.003	3	3
LUAD	ASB12 →	-0.241	-2.917	.005	.001	3	3
SKCM	PDE6B →	-0.438	-2.283	.004	.006	3	3
UCEC	RN7SKP286 →	+0.042	+3.973	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,885 associations by consensus.

BEX4 by SIRPG expression — UCEC

Explore this box plot interactively →