SIRPG

Across TCGA patient cohorts, SIRPG mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRPG-associated genes across cancer lineages are Caspase-7-cleavedD198, p90 RSK, and Caspase-8. Each is linked with SIRPG in more than 2 cancer types. Because this analysis shows association rather than direction, both SIRPG-to-partner and partner-to-SIRPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SIRPG-low versus SIRPG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPG→partner) and Y-score (partner→SIRPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.547	+2.189	.034	.034	3	3
SKCM	p90 RSK →	+0.172	+1.874	.020	.047	3	2
SKCM	Caspase-8 →	-0.104	-2.425	.041	.017	3	2
UCEC	Notch1 →	+0.228	+2.183	<.001	.033	3	2
SKCM	PARP_cleaved →	+0.145	+2.222	.008	.008	3	1
SKCM	AMPK_alpha →	+0.123	+2.222	.012	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by SIRPG expression — UCEC

Explore this box plot interactively →