SIRPG

Across TCGA cell cohorts, SIRPG mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SIRPG-associated genes across cancer lineages are TCP10L2, LIPN, and OR10C1. Each is linked with SIRPG in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRPG-to-partner and partner-to-SIRPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP10L2 grouped by SIRPG-low versus SIRPG-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPG→partner) and Y-score (partner→SIRPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TCP10L2 →	+0.054	+4.472	<.001	.001	3	1
LUNG_NSCLC_LUAD	LIPN →	+0.027	+5.362	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.040	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR52B2 →	+0.039	+4.215	<.001	.002	3	1
SKIN	C9orf129 →	+0.245	+3.544	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TCP10L2 by SIRPG expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →