SIRPD

Across TCGA patient cohorts, SIRPD mutation is significantly associated with the RNA expression of many other genes, with 862 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRPD-associated genes across cancer lineages are RN7SL837P, MIR4769, and CYCTP. Each is linked with SIRPD in more than 2 cancer types. Because this analysis shows association rather than direction, both SIRPD-to-partner and partner-to-SIRPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL837P grouped by SIRPD-low versus SIRPD-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPD→partner) and Y-score (partner→SIRPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL837P →	+0.484	+4.853	<.001	.004	3	3
UCEC	MIR4769 →	+0.212	+3.027	.007	.007	3	3
CESC	CYCTP →	+0.519	+5.306	<.001	.006	3	2
COAD	LINC00486 →	+0.123	+4.085	.004	.005	3	2
LUSC	LINC02276 →	+0.356	+3.652	<.001	.009	3	2
LUAD	OR5BE1P →	+0.049	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 862 associations by consensus.

RN7SL837P by SIRPD expression — LUSC

Explore this box plot interactively →