SIRPD

Across TCGA patient cohorts, SIRPD mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRPD-associated genes across cancer lineages are JNK2, MEK1, and PAI-1. Each is linked with SIRPD in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRPD-to-partner and partner-to-SIRPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SIRPD-low versus SIRPD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPD→partner) and Y-score (partner→SIRPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.291	+3.331	.001	.005	3	1
UCEC	MEK1 →	+0.431	+2.584	.011	.011	3	1
UCEC	PAI-1 →	+0.458	+2.584	.004	.011	3	1
UCEC	Stathmin →	+0.170	+2.833	.007	.034	3	1
UCEC	AR →	-0.420	-3.321	.015	.010	3	1
UCEC	Beclin →	+0.129	+3.000	.003	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

JNK2 by SIRPD expression — UCEC

Explore this box plot interactively →