Across TCGA patient cohorts, SIRPB2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,228 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIRPB2-associated genes across cancer lineages are MFNG, NCF4, and AHSA1. Each is linked with SIRPB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRPB2-to-partner and partner-to-SIRPB2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPB2→partner) and Y-score (partner→SIRPB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MFNG →	+0.799	+0.475	.005	.007	3	1
LSCC	NCF4 →	+0.886	+0.636	<.001	<.001	3	1
LSCC	AHSA1 →	-0.751	-0.682	.005	.003	3	1
LSCC	SIRPB1 →	+0.807	+0.758	<.001	<.001	3	1
LSCC	ZNF629 →	-0.848	-0.766	.005	.002	3	1
LSCC	PSMD7 →	-0.764	-0.638	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,228 associations by consensus.

Exploration

SIRPB2 survival (RNA) · tumor vs normal (RNA) · all SIRPB2 data types