Across TCGA patient cohorts, SIRPB2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRPB2-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and eEF2. Each is linked with SIRPB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRPB2-to-partner and partner-to-SIRPB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPB2→partner) and Y-score (partner→SIRPB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.841	+3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.106	-3.295	.008	.009	3	1
UCEC	eEF2 →	+0.364	+2.000	.011	.030	3	1
UCEC	FoxM1 →	+0.305	+2.415	.003	.003	3	1
UCEC	Gab2 →	+0.379	+3.000	.008	.036	3	1
UCEC	GATA6 →	-0.137	-2.985	.031	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

SIRPB2 survival (RNA) · tumor vs normal (RNA) · all SIRPB2 data types