Across TCGA cell cohorts, SIRPB2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIRPB2-associated genes across cancer lineages are SLC28A1, TACR3, and OR10Q1. Each is linked with SIRPB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRPB2-to-partner and partner-to-SIRPB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPB2→partner) and Y-score (partner→SIRPB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC28A1 →	+0.023	+4.191	<.001	.007	3	1
BLOOD_Leukemia	TACR3 →	+0.019	+4.060	.001	.003	3	1
BLOOD_Leukemia	OR10Q1 →	+0.021	+4.384	<.001	.006	3	1
BLOOD_Leukemia	VWC2 →	+0.412	+3.551	<.001	.009	3	1
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CCT8L2 →	+0.015	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

SIRPB2 survival (RNA) · tumor vs normal (RNA) · all SIRPB2 data types