SIRPB1

Across TCGA patient cohorts, SIRPB1 mutation is significantly associated with the RNA expression of many other genes, with 3,196 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRPB1-associated genes across cancer lineages are RPL32P19, RTCB, and PSMD11. Each is linked with SIRPB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIRPB1-to-partner and partner-to-SIRPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL32P19 grouped by SIRPB1-low versus SIRPB1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPB1→partner) and Y-score (partner→SIRPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RPL32P19 →	+0.168	+4.653	<.001	.007	3	3
UCEC	RTCB →	+0.401	+2.861	.005	.001	3	3
UCEC	PSMD11 →	+0.431	+2.606	.001	<.001	3	3
UCEC	LRRC59 →	+0.543	+2.745	<.001	<.001	3	3
UCEC	HSPA9 →	+0.471	+2.446	<.001	.001	3	3
UCEC	ARPP19 →	+0.401	+1.895	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,196 associations by consensus.

RPL32P19 by SIRPB1 expression — READ

Explore this box plot interactively →