SIRPB1

Across TCGA patient cohorts, SIRPB1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRPB1-associated genes across cancer lineages are 4E-BP1, HER3, and Rb_pS807_S811. Each is linked with SIRPB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIRPB1-to-partner and partner-to-SIRPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SIRPB1-low versus SIRPB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPB1→partner) and Y-score (partner→SIRPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.205	+1.904	.039	.029	3	3
SKCM	HER3 →	+0.266	+1.502	.035	.025	3	2
SKCM	Rb_pS807_S811 →	+0.326	+1.064	.014	.045	3	2
UCEC	A-Raf_pS299 →	-0.145	-3.700	<.001	.001	3	2
UCEC	p21 →	+0.222	+3.906	.001	<.001	3	2
UCEC	Shc_pY317 →	-0.154	-3.169	.005	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

4E-BP1 by SIRPB1 expression — UCEC

Explore this box plot interactively →