Across TCGA patient cohorts, SIRPA protein abundance is significantly associated with the RNA expression of many other genes, with 15,514 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIRPA-associated genes across cancer lineages are SAMSN1, HCK, and MEFV. Each is linked with SIRPA in more than 7 cancer types. Because this analysis shows association rather than direction, both SIRPA-to-partner and partner-to-SIRPA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPA→partner) and Y-score (partner→SIRPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SAMSN1 →	+0.864	+0.516	<.001	.001	3	8
UCEC	HCK →	+1.230	+0.565	<.001	<.001	3	7
LSCC	MEFV →	+0.646	+0.388	<.001	<.001	3	7
OV	LILRB1 →	+1.051	+0.578	<.001	<.001	3	7
UCEC	TYROBP →	+1.122	+0.608	<.001	<.001	3	7
COAD	SRGN →	+1.120	+0.498	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,514 associations by consensus.

Exploration

SIRPA survival (RNA) · tumor vs normal (RNA) · all SIRPA data types