Across TCGA patient cohorts, SIRPA protein abundance is significantly associated with the protein abundance of many other proteins, with 26,972 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SIRPA-associated proteins across cancer lineages are AMPD3, PLEKHO2, and PLXNC1. Each is linked with SIRPA in more than 8 cancer types. Because this analysis shows association rather than direction, both SIRPA-to-partner and partner-to-SIRPA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPA→partner) and Y-score (partner→SIRPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AMPD3 →	+0.603	+0.793	<.001	<.001	3	9
UCEC	PLEKHO2 →	+0.495	+0.729	<.001	<.001	3	8
UCEC	PLXNC1 →	+0.642	+0.702	<.001	<.001	3	8
GBM	PRKCB →	+0.725	+0.651	<.001	<.001	3	8
LSCC	RAB8B →	+0.432	+0.488	<.001	<.001	3	8
CCRCC	CD163 →	+0.665	+0.447	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 26,972 associations by consensus.

Exploration

SIRPA survival (RNA) · tumor vs normal (RNA) · all SIRPA data types