Across TCGA patient cohorts, SIRPA mutation is significantly associated with the RNA expression of many other genes, with 3,610 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRPA-associated genes across cancer lineages are MIR147A, IGLVVI-25-1, and PDCL2P2. Each is linked with SIRPA in more than 2 cancer types. Because this analysis shows association rather than direction, both SIRPA-to-partner and partner-to-SIRPA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPA→partner) and Y-score (partner→SIRPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR147A →	+0.092	+2.537	.001	.004	3	3
BRCA	IGLVVI-25-1 →	+0.084	+4.711	.001	.004	3	2
BRCA	PDCL2P2 →	+0.465	+4.703	<.001	<.001	3	2
BRCA	ZNF705B →	+0.030	+5.725	<.001	.001	3	2
BRCA	RNA5SP113 →	+0.264	+4.711	<.001	.004	3	2
BLCA	LINC02706 →	+0.068	+6.048	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,610 associations by consensus.

Exploration

SIRPA survival (RNA) · tumor vs normal (RNA) · all SIRPA data types