Across TCGA cell cohorts, SIRPA protein abundance is significantly associated with the RNA expression of many other genes, with 2,728 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIRPA-associated genes across cancer lineages are POT1, CEP131, and PCYT2. Each is linked with SIRPA in more than 3 cancer types. Because this analysis shows association rather than direction, both SIRPA-to-partner and partner-to-SIRPA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRPA→partner) and Y-score (partner→SIRPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	POT1 →	+0.662	+1.820	.003	.008	3	4
LUNG_NSCLC_LUAD	CEP131 →	+0.673	+1.366	.009	.004	3	3
SKIN	PCYT2 →	+1.102	+1.577	.006	.001	3	3
SKIN	HPCA →	+0.515	+1.610	<.001	<.001	3	3
STOMACH	STRADA →	+1.171	+1.820	<.001	.008	3	3
OESOPHAGUS	MMRN2 →	-1.686	-2.691	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,728 associations by consensus.

Exploration

SIRPA survival (RNA) · tumor vs normal (RNA) · all SIRPA data types