SIPA1L3

Across TCGA pan-cancer cohorts, SIPA1L3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SIPA1L3 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SIPA1L3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SIPA1L3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where SIPA1L3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.905	0.433	.024	16	view →
PDAC	OS	Quartile	All	0.945	0.638	.013	11	view →
LSCC	DFS	Median	All	0.453	0.868	.020	5	view →
LUAD	OS	Tertile	III,IV	0.719	0.378	.034	4	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	3	view →
GBM	OS	Median	All	0.911	0.800	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SIPA1L3–UCEC (DFS)

Open the UCEC breakdown →