SIPA1L3

Across TCGA patient cohorts, SIPA1L3 mutation is significantly associated with the RNA expression of many other genes, with 5,017 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIPA1L3-associated genes across cancer lineages are FANCA, BCCIP, and PFKFB4. Each is linked with SIPA1L3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIPA1L3-to-partner and partner-to-SIPA1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCA grouped by SIPA1L3-low versus SIPA1L3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L3→partner) and Y-score (partner→SIPA1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FANCA →	+0.660	+2.717	.003	.003	3	5
STAD	BCCIP →	+0.449	+3.807	.002	<.001	3	4
STAD	PFKFB4 →	+0.848	+3.610	<.001	.001	3	4
STAD	ZWINT →	+0.640	+3.807	.008	<.001	2	5
STAD	ELL3 →	+0.505	+3.334	.003	.005	3	4
STAD	KIF11 →	+0.754	+3.840	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,017 associations by consensus.

FANCA by SIPA1L3 expression — STAD

Explore this box plot interactively →