SIPA1L3

Across TCGA patient cohorts, SIPA1L3 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIPA1L3-associated genes across cancer lineages are ATM, Caveolin-1, and PDK1_pS241. Each is linked with SIPA1L3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIPA1L3-to-partner and partner-to-SIPA1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SIPA1L3-low versus SIPA1L3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L3→partner) and Y-score (partner→SIPA1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ATM →	-0.408	-3.000	.010	.034	2	4
STAD	Caveolin-1 →	-0.723	-2.321	.022	.030	3	3
LUSC	PDK1_pS241 →	-0.129	-2.450	.040	.019	3	3
UCEC	Lck →	+0.184	+1.807	.001	.024	3	3
COAD	Caspase-7-cleavedD198 →	+0.680	+3.169	.040	.018	3	3
COAD	Rad50 →	-0.316	-3.433	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ATM by SIPA1L3 expression — STAD

Explore this box plot interactively →