SIPA1L2

Across TCGA patient cohorts, SIPA1L2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,145 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIPA1L2-associated genes across cancer lineages are TRBV5-4, MARK1, and RBP7. Each is linked with SIPA1L2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIPA1L2-to-partner and partner-to-SIPA1L2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIPA1L2 versus TRBV5-4 in UCEC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L2→partner) and Y-score (partner→SIPA1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRBV5-4 →	-1.266	-0.382	<.001	<.001	3	4
LSCC	MARK1 →	+0.786	+0.348	<.001	<.001	3	4
CCRCC	RBP7 →	+1.344	+0.438	.002	.001	3	3
OV	EGFL7 →	+1.336	+1.217	<.001	<.001	3	3
UCEC	RN7SL801P →	+0.774	+0.287	.009	.005	3	3
HNSC	STAMBPL1 →	-0.866	-0.357	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,145 associations by consensus.

SIPA1L2 vs TRBV5-4 — UCEC

Explore this scatter interactively →