SIPA1L2

Across TCGA patient cohorts, SIPA1L2 mutation is significantly associated with the RNA expression of many other genes, with 7,561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIPA1L2-associated genes across cancer lineages are PSMA6, THOP1, and PSMC3IP. Each is linked with SIPA1L2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIPA1L2-to-partner and partner-to-SIPA1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA6 grouped by SIPA1L2-low versus SIPA1L2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L2→partner) and Y-score (partner→SIPA1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PSMA6 →	+0.331	+2.299	.006	.005	3	6
UCEC	THOP1 →	+0.635	+2.069	<.001	<.001	3	6
COAD	PSMC3IP →	+0.667	+3.114	<.001	<.001	3	6
UCEC	KIF2C →	+0.479	+1.536	.001	.001	3	6
UCEC	LMNB2 →	+0.679	+1.914	<.001	<.001	3	5
COAD	EXOSC9 →	+0.432	+2.263	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,561 associations by consensus.

PSMA6 by SIPA1L2 expression — SKCM

Explore this box plot interactively →