SIPA1L2

Across TCGA cell cohorts, SIPA1L2 mutation is significantly associated with the RNA expression of many other genes, with 1,491 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIPA1L2-associated genes across cancer lineages are GJB6, TTC21B, and UBE2G1. Each is linked with SIPA1L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIPA1L2-to-partner and partner-to-SIPA1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJB6 grouped by SIPA1L2-low versus SIPA1L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L2→partner) and Y-score (partner→SIPA1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJB6 →	+0.577	+3.722	<.001	<.001	3	3
LARGE_INTESTINE	TTC21B →	+0.479	+2.386	.003	.007	3	3
LARGE_INTESTINE	UBE2G1 →	+0.487	+2.537	.004	<.001	3	3
STOMACH	LCE1F →	+0.287	+3.794	<.001	.003	3	3
BLOOD_Leukemia	NEDD1 →	+0.943	+2.614	<.001	.003	3	3
BLOOD_Leukemia	ZNF624 →	+0.573	+3.789	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,491 associations by consensus.

GJB6 by SIPA1L2 expression — LARGE_INTESTINE

Explore this box plot interactively →