Across TCGA patient cohorts, SIPA1L1 mutation is significantly associated with the RNA expression of many other genes, with 7,873 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIPA1L1-associated genes across cancer lineages are MTHFD1, ZNF662, and LINC00865. Each is linked with SIPA1L1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIPA1L1-to-partner and partner-to-SIPA1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L1→partner) and Y-score (partner→SIPA1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTHFD1 →	+0.476	+1.425	<.001	<.001	3	5
LUAD	ZNF662 →	-0.730	-2.895	.001	.001	3	5
UCEC	LINC00865 →	-0.578	-1.550	<.001	<.001	3	5
STAD	NEK2 →	+0.655	+2.452	.001	.001	3	5
UCEC	ATP1B2 →	-0.667	-1.539	<.001	<.001	3	5
STAD	PELP1 →	+0.433	+1.564	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,873 associations by consensus.

Exploration

SIPA1L1 survival (RNA) · tumor vs normal (RNA) · all SIPA1L1 data types