Across TCGA patient cohorts, SIPA1L1 mutation is significantly associated with the total protein of many other genes, with 101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIPA1L1-associated genes across cancer lineages are Caspase-7-cleavedD198, Bap1-c-4, and Cyclin-B1. Each is linked with SIPA1L1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIPA1L1-to-partner and partner-to-SIPA1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L1→partner) and Y-score (partner→SIPA1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.792	+3.016	.008	.018	3	5
STAD	Bap1-c-4 →	+0.364	+3.584	.003	.002	3	4
UCEC	Cyclin-B1 →	+0.581	+2.807	<.001	<.001	3	4
UCEC	eIF4E →	+0.177	+1.584	.002	<.001	3	4
STAD	eIF4G →	+0.396	+1.765	.026	.012	3	3
SKCM	Akt_pT308 →	-0.356	-1.247	.036	.043	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

Exploration

SIPA1L1 survival (RNA) · tumor vs normal (RNA) · all SIPA1L1 data types