Across TCGA cell cohorts, SIPA1L1 mutation is significantly associated with the RNA expression of many other genes, with 1,065 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIPA1L1-associated genes across cancer lineages are TMEM31, C1orf146, and OR6B3. Each is linked with SIPA1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIPA1L1-to-partner and partner-to-SIPA1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L1→partner) and Y-score (partner→SIPA1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TMEM31 →	+0.170	+3.115	.003	.006	3	2
CNS	C1orf146 →	+0.022	+3.459	<.001	.006	3	2
BLOOD_Lymphoma	OR6B3 →	+0.030	+3.523	<.001	.009	3	2
BLOOD_Leukemia	PAX1 →	+0.034	+3.890	<.001	<.001	3	2
OVARY	OR8B12 →	+0.011	+3.807	<.001	.009	3	2
OVARY	GSTA3 →	+0.041	+3.754	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,065 associations by consensus.

Exploration

SIPA1L1 survival (RNA) · tumor vs normal (RNA) · all SIPA1L1 data types