Across TCGA pan-cancer cohorts, SIPA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SIPA1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SIPA1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SIPA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and GBM are the cancer types where SIPA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.818	0.605	.006	17	view →
LUAD	DFS	Median	II,III,IV	0.694	0.370	.036	4	view →
GBM	DFS	Quartile	All	0.224	0.419	.022	2	view →
LSCC	DFS	Tertile	All	0.852	0.397	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SIPA1 tumor-vs-normal RNA expression · all SIPA1 data types