Across TCGA patient cohorts, SIPA1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,012 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIPA1-associated proteins across cancer lineages are STK10, CORO1A, and GNAI2. Each is linked with SIPA1 in more than 7 cancer types. Because this analysis shows association rather than direction, both SIPA1-to-partner and partner-to-SIPA1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1→partner) and Y-score (partner→SIPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STK10 →	+0.369	+0.645	<.001	<.001	3	8
OV	CORO1A →	+0.693	+0.623	.001	.001	3	8
COAD	GNAI2 →	+0.255	+0.472	<.001	<.001	3	8
GBM	HCLS1 →	+0.788	+0.751	<.001	<.001	3	8
GBM	LCP1 →	+0.800	+0.637	<.001	<.001	3	8
GBM	LCP2 →	+0.519	+0.534	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,012 associations by consensus.

Exploration

SIPA1 survival (RNA) · tumor vs normal (RNA) · all SIPA1 data types