Across TCGA patient cohorts, SIPA1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIPA1-associated genes across cancer lineages are HER3_pY1289, Ku80, and Rb_pS807_S811. Each is linked with SIPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIPA1-to-partner and partner-to-SIPA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1→partner) and Y-score (partner→SIPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.091	+2.611	.023	.006	3	2
UCEC	Ku80 →	+0.401	+3.469	<.001	.002	3	1
UCEC	Rb_pS807_S811 →	-0.445	-3.000	.018	.036	3	1
UCEC	Bak →	+0.270	+2.321	.020	.034	3	1
UCEC	4E-BP1 →	+0.262	+2.837	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

SIPA1 survival (RNA) · tumor vs normal (RNA) · all SIPA1 data types