Across TCGA cell cohorts, SIPA1 mutation is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIPA1-associated genes across cancer lineages are IDI2, SCT, and IQCF1. Each is linked with SIPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIPA1-to-partner and partner-to-SIPA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1→partner) and Y-score (partner→SIPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IDI2 →	+0.033	+5.087	<.001	.004	3	2
URINARY_TRACT	SCT →	+0.153	+5.087	<.001	.004	3	2
OVARY	IQCF1 →	+0.284	+3.836	<.001	.003	3	2
BLOOD_Leukemia	DNAAF6 →	+0.018	+2.655	.009	.001	3	2
SOFT_TISSUE	SIGLEC8 →	+0.196	+5.977	<.001	.001	3	1
SOFT_TISSUE	FAM90A26 →	+0.016	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

Exploration

SIPA1 survival (RNA) · tumor vs normal (RNA) · all SIPA1 data types