SIN3B

Across TCGA pan-cancer cohorts, SIN3B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SIN3B data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SIN3B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SIN3B expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

UCEC, GBM, and PDAC are the cancer types where SIN3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.899	1.000	.029	8	view →
GBM	DFS	Median	All	0.840	0.670	.025	3	view →
PDAC	DFS	Tertile	II,III,IV	0.606	0.398	.040	2	view →
HNSC	OS	Median	All	0.995	0.940	.032	2	view →
LUAD	DFS	Median	II,III,IV	0.781	0.311	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SIN3B–UCEC (OS)

Open the UCEC breakdown →