SIN3B

Across TCGA patient cohorts, SIN3B mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIN3B-associated genes across cancer lineages are MEK1, ATM, and PCNA. Each is linked with SIN3B in more than 2 cancer types. Because this analysis shows association rather than direction, both SIN3B-to-partner and partner-to-SIN3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SIN3B-low versus SIN3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIN3B→partner) and Y-score (partner→SIN3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.465	+1.893	<.001	<.001	3	3
UCEC	ATM →	-0.678	-2.723	<.001	<.001	3	3
UCEC	PCNA →	+0.240	+2.502	<.001	.001	3	3
SKCM	eIF4G →	+0.329	+1.700	.049	.043	3	2
SKCM	Smad4 →	+0.122	+3.356	.010	.004	3	2
UCEC	STAT3_pY705 →	-0.521	-2.857	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

MEK1 by SIN3B expression — UCEC

Explore this box plot interactively →