SIN3B

Across TCGA cell cohorts, SIN3B mutation is significantly associated with the RNA expression of many other genes, with 546 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIN3B-associated genes across cancer lineages are GLYATL3, PRR30, and ARL6. Each is linked with SIN3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SIN3B-to-partner and partner-to-SIN3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLYATL3 grouped by SIN3B-low versus SIN3B-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIN3B→partner) and Y-score (partner→SIN3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	2
BLOOD_Leukemia	PRR30 →	+0.015	+3.269	<.001	.007	3	2
LARGE_INTESTINE	ARL6 →	+0.455	+2.743	.003	.001	3	2
LARGE_INTESTINE	GATAD2B →	+0.494	+2.043	.002	.008	3	2
LARGE_INTESTINE	RGPD5 →	+0.934	+2.743	.003	.001	3	2
LARGE_INTESTINE	NIPSNAP1 →	+0.613	+2.043	.009	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 546 associations by consensus.

GLYATL3 by SIN3B expression — KIDNEY

Explore this box plot interactively →