SIMC1

Across TCGA patient cohorts, SIMC1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIMC1-associated genes across cancer lineages are MEK1, 4E-BP1, and EGFR_pY1068. Each is linked with SIMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIMC1-to-partner and partner-to-SIMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SIMC1-low versus SIMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIMC1→partner) and Y-score (partner→SIMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.465	+2.432	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.251	+3.807	.003	<.001	3	3
UCEC	EGFR_pY1068 →	-0.214	-1.502	.006	.027	3	2
UCEC	eIF4E →	+0.144	+2.472	.030	.010	3	2
UCEC	MSH6 →	-0.259	-2.000	.012	.029	3	2
UCEC	mTOR_pS2448 →	-0.117	-1.353	.012	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MEK1 by SIMC1 expression — UCEC

Explore this box plot interactively →