SIMC1

Across TCGA cell cohorts, SIMC1 RNA expression is significantly associated with the RNA expression of many other genes, with 9,679 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIMC1-associated genes across cancer lineages are LRP3, ZNF346, and TUB. Each is linked with SIMC1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SIMC1-to-partner and partner-to-SIMC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIMC1 versus LRP3 in STOMACH, with a Pearson correlation of 0.51.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIMC1→partner) and Y-score (partner→SIMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LRP3 →	+2.464	+1.487	<.001	<.001	3	13
LARGE_INTESTINE	ZNF346 →	+0.869	+0.674	<.001	<.001	3	10
LIVER	TUB →	+2.058	+1.516	<.001	<.001	3	10
BLOOD_Lymphoma	PPP2R3B →	+1.495	+1.763	.001	<.001	3	10
KIDNEY	PHF2 →	+1.132	+1.010	.003	<.001	3	9
LUNG_NSCLC_LUSC	MAML1 →	+1.048	+1.104	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,679 associations by consensus.

SIMC1 vs LRP3 — STOMACH

Explore this scatter interactively →