SIMC1

Across TCGA cell cohorts, SIMC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,635 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SIMC1-associated GO terms across cancer lineages are Cell cycle phase transition, Establishment of mitotic spindle localization, and Transcription initiation at RNA polymerase II promoter. Each is linked with SIMC1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SIMC1-to-partner and partner-to-SIMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle phase transition grouped by SIMC1-low versus SIMC1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIMC1→partner) and Y-score (partner→SIMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Cell cycle phase transition →	+0.109	+0.898	<.001	<.001	3	14
SOFT_TISSUE	Establishment of mitotic spindle localization →	+0.164	+1.100	<.001	<.001	3	13
BONE	Transcription initiation at RNA polymerase II promoter →	+0.072	+0.722	.001	.001	3	13
KIDNEY	Regulation of chromosome segregation →	+0.117	+0.892	<.001	<.001	3	12
BONE	RNA localization →	+0.101	+0.795	<.001	<.001	3	12
STOMACH	RNA export from nucleus →	+0.113	+1.343	.002	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,635 associations by consensus.

Cell cycle phase transition by SIMC1 expression — SOFT_TISSUE

Explore this box plot interactively →