SIMC1

Across TCGA cell cohorts, SIMC1 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIMC1-associated genes across cancer lineages are HELT, RBMY1J, and PRR23C. Each is linked with SIMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIMC1-to-partner and partner-to-SIMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELT grouped by SIMC1-low versus SIMC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIMC1→partner) and Y-score (partner→SIMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HELT →	+0.022	+5.209	<.001	.005	3	1
OVARY	RBMY1J →	+0.011	+3.807	<.001	.009	3	1
OVARY	PRR23C →	+0.007	+3.405	<.001	.005	3	1
OVARY	RBMY1A1 →	+0.071	+3.807	.001	.009	3	1
LARGE_INTESTINE	TBR1 →	+0.053	+3.333	<.001	.009	2	2
LARGE_INTESTINE	BRDT →	+0.095	+3.333	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

HELT by SIMC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →