SIM2

Across TCGA patient cohorts, SIM2 mutation is significantly associated with the RNA expression of many other genes, with 3,869 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIM2-associated genes across cancer lineages are DHRS11, PIN1, and MIR8053. Each is linked with SIM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIM2-to-partner and partner-to-SIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHRS11 grouped by SIM2-low versus SIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM2→partner) and Y-score (partner→SIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHRS11 →	+0.617	+3.119	<.001	<.001	3	3
UCEC	PIN1 →	+0.397	+3.194	.001	<.001	3	3
COAD	MIR8053 →	+0.277	+4.399	<.001	.006	3	3
LIHC	RNA5SP53 →	+0.182	+5.169	<.001	.002	3	2
UCEC	DDX52 →	+0.376	+1.545	.009	.005	3	2
BLCA	RNU1-35P →	+0.375	+4.314	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,869 associations by consensus.

DHRS11 by SIM2 expression — UCEC

Explore this box plot interactively →