SIM2

Across TCGA patient cohorts, SIM2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIM2-associated genes across cancer lineages are PCNA, ATM, and 14-3-3_beta. Each is linked with SIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIM2-to-partner and partner-to-SIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SIM2-low versus SIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM2→partner) and Y-score (partner→SIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.175	+1.807	.027	.025	3	2
UCEC	ATM →	-0.518	-1.847	.001	.008	3	2
UCEC	14-3-3_beta →	-0.112	-3.673	.002	.001	3	1
UCEC	EGFR_pY1068 →	-0.191	-1.502	.038	.030	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.115	.001	.017	3	1
UCEC	ERK2 →	+0.183	+2.321	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

PCNA by SIM2 expression — UCEC

Explore this box plot interactively →