SIM2

Across TCGA cell cohorts, SIM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,521 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SIM2-associated GO terms across cancer lineages are Vesicle-mediated transport to the plasma membrane, Negative regulation of myoblast fusion, and Negative regulation of mRNA processing. Each is linked with SIM2 in more than 7 cancer types. Because this analysis shows association rather than direction, both SIM2-to-partner and partner-to-SIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle-mediated transport to the plasma membrane grouped by SIM2-low versus SIM2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM2→partner) and Y-score (partner→SIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Vesicle-mediated transport to the plasma membrane →	+0.055	+1.741	<.001	.003	3	7
BONE	Negative regulation of myoblast fusion →	+0.093	+2.593	<.001	<.001	3	7
PANCREAS	Negative regulation of mRNA processing →	+0.069	+1.280	<.001	<.001	3	7
BONE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.090	+2.559	<.001	<.001	3	6
SKIN	COPII-coated vesicle cargo loading →	+0.082	+0.947	.004	.007	3	6
URINARY_TRACT	Cellular response to reactive oxygen species →	+0.060	+1.259	.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,521 associations by consensus.

Vesicle-mediated transport to the plasma membrane by SIM2 expression — SOFT_TISSUE

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