SIM2

Across TCGA cell cohorts, SIM2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIM2-associated genes across cancer lineages are ELSPBP1, SLCO1C1, and ECE2. Each is linked with SIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIM2-to-partner and partner-to-SIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELSPBP1 grouped by SIM2-low versus SIM2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM2→partner) and Y-score (partner→SIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ELSPBP1 →	+0.204	+4.108	.005	.005	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.538	+3.772	<.001	.003	3	1
LARGE_INTESTINE	ECE2 →	+0.295	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	TSPY2 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	ARGFX →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	SCYGR2 →	+0.043	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ELSPBP1 by SIM2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →