SIM1

Across TCGA patient cohorts, SIM1 RNA expression is significantly associated with the RNA expression of many other genes, with 14,186 significant associations in total. KIRP shows the largest number of these associations.

The most reproducible SIM1-associated genes across cancer lineages are SIM1-AS1, NUAK1, and TMEM263. Each is linked with SIM1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SIM1-to-partner and partner-to-SIM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIM1 versus SIM1-AS1 in KICH, with a Pearson correlation of 0.52.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM1→partner) and Y-score (partner→SIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	SIM1-AS1 →	+0.501	+1.584	<.001	<.001	3	17
TGCT	NUAK1 →	+1.113	+0.379	<.001	<.001	3	14
KIRP	TMEM263 →	+0.867	+1.278	<.001	<.001	3	12
TGCT	FBXO5 →	+0.800	+0.460	<.001	.002	3	12
KICH	CRY1 →	+1.326	+1.767	<.001	<.001	3	12
KICH	GXYLT1 →	+0.837	+1.133	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,186 associations by consensus.

SIM1 vs SIM1-AS1 — KICH

Explore this scatter interactively →