SIM1

Across TCGA patient cohorts, SIM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,066 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SIM1-associated GO terms across cancer lineages are Negative regulation of protein ubiquitination, Nuclear membrane reassembly, and Regulation of proteasomal ubiquitin-dependent protein catabolic process. Each is linked with SIM1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SIM1-to-partner and partner-to-SIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein ubiquitination grouped by SIM1-low versus SIM1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM1→partner) and Y-score (partner→SIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of protein ubiquitination →	+0.075	+0.031	<.001	<.001	3	15
STAD	Nuclear membrane reassembly →	+0.079	+0.028	<.001	<.001	3	14
STAD	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.072	+0.026	<.001	<.001	3	14
STAD	DNA-templated transcription initiation →	+0.076	+0.030	<.001	<.001	3	14
STAD	Cellular response to radiation →	+0.071	+0.032	<.001	<.001	3	13
STAD	Regulation of cellular response to transforming growth factor beta stimulus →	+0.056	+0.031	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,066 associations by consensus.

Negative regulation of protein ubiquitination by SIM1 expression — STAD

Explore this box plot interactively →