SIM1

Across TCGA patient cohorts, SIM1 protein abundance is significantly associated with the RNA expression of many other genes, with 541 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SIM1-associated genes across cancer lineages are SPRTN, PSMB5, and RIMS4. Each is linked with SIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIM1-to-partner and partner-to-SIM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIM1 versus SPRTN in CCRCC, with a Pearson correlation of -0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM1→partner) and Y-score (partner→SIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SPRTN →	-0.456	-0.750	.002	<.001	3	1
CCRCC	PSMB5 →	-0.503	-0.628	.006	<.001	3	1
CCRCC	RIMS4 →	+0.046	+0.685	.001	.002	3	1
CCRCC	MROH8 →	+0.735	+0.846	.003	.005	3	1
CCRCC	GABRE →	-1.691	-0.715	.006	.001	3	1
CCRCC	MAGED2 →	-0.788	-0.623	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 541 associations by consensus.

SIM1 vs SPRTN — CCRCC

Explore this scatter interactively →