SIM1

Across TCGA patient cohorts, SIM1 mutation is significantly associated with the RNA expression of many other genes, with 5,355 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIM1-associated genes across cancer lineages are COQ3, RNF126, and MRPS33. Each is linked with SIM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIM1-to-partner and partner-to-SIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ3 grouped by SIM1-low versus SIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM1→partner) and Y-score (partner→SIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COQ3 →	+0.430	+1.439	<.001	<.001	3	5
UCEC	RNF126 →	+0.451	+1.782	<.001	<.001	3	4
UCEC	MRPS33 →	+0.306	+1.338	.004	.007	3	4
STAD	NANS →	+0.725	+3.355	<.001	.005	3	4
UCEC	PSMD9 →	+0.332	+2.180	<.001	<.001	3	4
UCEC	GMNN →	+0.626	+2.136	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,355 associations by consensus.

COQ3 by SIM1 expression — UCEC

Explore this box plot interactively →