SIM1

Across TCGA patient cohorts, SIM1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIM1-associated genes across cancer lineages are TFRC, eEF2K, and STAT5a. Each is linked with SIM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIM1-to-partner and partner-to-SIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SIM1-low versus SIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM1→partner) and Y-score (partner→SIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.433	+2.321	.005	.005	3	3
UCEC	eEF2K →	+0.234	+1.584	.022	.034	3	3
LUAD	STAT5a →	+0.392	+2.338	.042	.019	3	2
UCEC	ERK2 →	+0.154	+1.765	.006	.011	3	2
UCEC	FoxM1 →	+0.152	+1.241	.046	.015	3	2
UCEC	Heregulin →	-0.112	-1.523	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

TFRC by SIM1 expression — UCEC

Explore this box plot interactively →