SIM1

Across TCGA cell cohorts, SIM1 mutation is significantly associated with the RNA expression of many other genes, with 258 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIM1-associated genes across cancer lineages are NDUFAF4, ZCCHC2, and GCAT. Each is linked with SIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIM1-to-partner and partner-to-SIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF4 grouped by SIM1-low versus SIM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM1→partner) and Y-score (partner→SIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NDUFAF4 →	+0.672	+3.169	<.001	.009	3	2
SKIN	ZCCHC2 →	+0.536	+3.212	<.001	.006	3	2
LARGE_INTESTINE	GCAT →	+1.325	+3.502	<.001	.001	3	1
LARGE_INTESTINE	CBY1 →	+0.787	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	KCTD17 →	+0.960	+3.502	.002	.001	3	1
LARGE_INTESTINE	C1QBP →	+0.851	+3.588	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 258 associations by consensus.

NDUFAF4 by SIM1 expression — LARGE_INTESTINE

Explore this box plot interactively →