Across TCGA pan-cancer cohorts, SIM1-AS1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated SIM1-AS1 data layer.
The strongest signal is observed in brain lower grade glioma (LGG), where higher SIM1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SIM1-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCS show a favorable association.
LGG, SARC, and LUAD are the cancer types where SIM1-AS1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.